Researchers discover key biochemical mechanism in Huntington's disease development
Researchers from the University of Oxford have identified a key biochemical mechanism relevant to the development of Huntington's Disease. This discovery opens up the possibility of studying the disease before its clinical onset and eventually stopping its progression. The study, published in Nature Metabolism, has shown for the first time the biochemical change responsible for the development of Huntington's disease, and how blocking this change stopped disease progression. Huntington's disease is an inherited condition that stops parts of the brain from working properly, leading to mental and physical decline that slowly worsens over time. The symptoms usually begin to appear after the age of 30 years and are fatal, but this can be after a period of up to 20 years, during which they worsen. The study explores how an early change described in the brain of HD patients in the early 1980s could lead to Huntington's disease onset. The researchers identified that problems ...